POLIMORFISME GEN ALPHA ACTININ-3 (ACTN 3) BERHUBUNGAN DENGAN MUSCLE PERFOMANCE ATLET
نویسندگان
چکیده
منابع مشابه
Alpha-actinin-3 R577X Polymorphism Profile of Turkish Professional Hip-Hop and Latin Dancers
Actins are small globular filaments functioning in cell processes like muscle contraction, and stabilized to the sarcomeric Z- discs by actin binding proteins (actinins). One of the important gene coding for actin binding proteins in fast twitch fibers is alpha- actinin- 3 (ACTN3). In this research, we have conducted a gene profile study investigating the genotype and allele distributions of AC...
متن کاملalpha-actinin-3 r577x polymorphism profile of turkish professional hip-hop and latin dancers
actins are small globular filaments functioning in cell processes like muscle contraction, and stabilized to the sarcomeric z- discs by actin binding proteins (actinins). one of the important gene coding for actin binding proteins in fast twitch fibers is alpha- actinin- 3 (actn3). in this research, we have conducted a gene profile study investigating the genotype and allele distributions of ac...
متن کاملRole of Alpha-actinin-3 in Contractile Properties of Human Single Muscle Fibers: A Case Series Study in Paraplegics
A common nonsense polymorphism in the ACTN3 gene results in the absence of α-actinin-3 in XX individuals. The wild type allele has been associated with power athlete status and an increased force output in numeral studies, though the mechanisms by which these effects occur are unclear. Recent findings in the Actn3(-/-) (KO) mouse suggest a shift towards 'slow' metabolic and contractile characte...
متن کاملHuman skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.
Alpha-actinins belong to a family of actin-binding and crosslinking proteins and are expressed in many different cell types. Multiple isoforms of alpha-actinin are found in humans and are encoded by at least four distinct genes. Human skeletal muscle contains two sarcomeric isoforms, alpha-actinin-2 and -3. Previous studies have shown that the alpha-actinins function as anti-parallel homodimers...
متن کاملA 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region.
Cryoelectron microscopy was used to obtain a 3-D image at 2.0 nm resolution of 2-D arrays of smooth muscle alpha-actinin. The reconstruction reveals a well-resolved long central domain with 90 degrees of left-handed twist and near 2-fold symmetry. However, the molecular ends which contain the actin binding and calmodulin-like domains, have different structures oriented approximately 90 degrees ...
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ژورنال
عنوان ژورنال: Sport and Fitness Journal
سال: 2019
ISSN: 2654-9182,2302-688X
DOI: 10.24843/spj.2019.v07.i03.p03